Thank you Graham!!

Well I would always suggest an aisle seat, so you can have a walk around, and if you need the toilets, you aren't asking people to move.
However........something else to consider is how long your flight is, and at what time. If you get a window seat, you can more likely position yourself into a decent sleeping position. Even better of course if the flight isn't full and you can get a couple of seats to yourself, but this is very hit and miss as to when it happens.

Yes babies, it must be one of those laws of physics that every long haul night flight has to have a baby on it They don't bother me personally THAT much, but to some people......well that's an entirely different thread, let's not go there.

Now if you are bothered by turbulence, then the most stable area is near the wings. The rear of the plane can by comparison be like a big dipper. I actually put this to the test on a bumpy flight once, walking to the end and there is definitely a difference, more of a wobble at the rear (sounds like a dodgy curry aftermath that)

I've never been able to choose a seat near a block end with the extra leg room, and suspect the airlines sell these at a premium, but I'm not that tall anyway, so it's nothing to me - might be with you, only you will know.