It's hard!
I do long hours and my wife works pretty much full time as a nurse. She does 3 shifts per week, each over 12 hours. Sometimes they fall on a weekend or overnight though. We just end up paying a fortune on childcare! We're lucky that the nursery we use is very flexible and is open from 6.45am until 6pm.
Now that our son is 3 years old, we qualify for the Government's early years grant, which pays for 15 hours per week during term time.
I also don't have a large network of relatives to call on. My mother looks after him for one afternoon per week, but I that tires her out enough!