I have not used vista at all.
here are some of the problems I get every day! with w2k/xp

my experience with XP is that is has lots of graphics problems. When I alt-tab the icons don't draw properly - pointless feature & doesnt work properly.

the curved edges on the windows are not anti aliased

both systems. delete a directory & the folder will still show up, click on it it will tell you it doesn't exist

log on/off from xp, the 'workstation locked' dialog doesn't redraw.

password expires tommorow, it says 'your password expires in 1 days'

in word, insert a picture, insert another one.. back to the old directory - not where you were...

if an application locks up, drag another window over it & you can make pretty patterns

in xp my mouse keeps jumping around. mostly keeps going to the bottom left corner .. but not all the time

hit F5 in explorer & it doesn't refresh directories, only files (I think there is a registry hack to fix this?).

recent documents does not delete document that have been deleted already (this has been like this for over 10years!!! still not fixed)

you can connect to another machine with different users (i.e. connect a network drive as one user), then it stops you logging in
then dont get me started on applications

and I'm betting none of those are fixed in vista