Morning Steve,

Obviously a lot depends on what you want out of a weekend away. About 10 years ago I used to have a 3 or 4 day weekend away nearly every month, and there's lots of places I wouldn't bother going back to, but a few I would recommend are:-
1. Istanbul
2. Porto
3. Florence
4. Dublin

I've heard that Faro is nice if you want a beach, but haven't been there myself.