I have been to Italy a few times but not with my wife yet. Rimini, Lake Garda and Venice. If we do go then it would be a round trip of Rome, Pisa (Tuscany) and Pompeii.

One thing i must say is if you are going to Venice do not sit in St Marks Square and order a coffee or any drinks. You will be seriously robbed of Euros. The back streets just off the square are a lot cheaper.