Personally I'm an avid aisle seater.
I want good access to the CR easy access to the aisle for a leg stretch and 'on-demand' access to the galley for snacks and champers.
It's also a better starting position for getting to an emergency exit.
These are my key issues and to secure them I'm willing to put up with making way for those seated in windows and middles. I'm also happy to put up with the brushing contacts with passing crew and food trolley.

Probably use aisle seaters have to more aware of items falling out of overhead lockers.
Better to be sure you duly utilise that space with your own stuff

What's your seat preference ?
and why ?